A history of partial reprogramming: a semi-comprehensive list of papers

Last updated: Jan 18, 2025

2006

• Takahishi and Yamanaka: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

2008

• Sridharan et al.: Role of the murine reprogramming factors in the induction of pluripotency

  • First mention of partial reprogramming, but not related to rejuvenation

2010

• Marión and Blasco: Telomere rejuvenation during nuclear reprogramming

• Singh and Zacouto: Nuclear reprogramming and epigenetic rejuvenation

  • First proposal of rejuvenation through reprogramming

• Shur et al.: Mitochondrial Rejuvenation After Induced Pluripotency

2011

• Lapasset et al.: Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

  • First demonstration of rejuvenation using reprogramming with OSKM

2012

• Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock

2013

• Abad et al.: Reprogramming in vivo produces teratomas and iPS cells with totipotency features

  • First demonstration of in vivo reprogramming with OSKM

2014

• Ohnishi et al.: Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation

• Epigenome rejuvenation: HP1β mobility as a measure of pluripotent and senescent chromatin ground states

  • First demonstration that rejuvenation with OSKM and de-differentiation can be decoupled

2016

• Seo et al.: In Situ Pluripotency Factor Expression Promotes Functional Recovery From Cerebral Ischemia

• Ocampo et al.: In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

  • Landmark paper: First in vivo partial reprogramming with OSKM that shows rejuvenation of progeroid mice without teratomas

2017

• Guo et al.: Generation of Induced Progenitor-like Cells from Mature Epithelial Cells Using Interrupted Reprogramming

2018

• Doeser et al.: Reduction of Fibrosis and Scar Formation by Partial Reprogramming In Vivo

• Gobel et al.: Interrupted reprogramming into induced pluripotent stem cells does not rejuvenate human mesenchymal stromal cells

• Olova et al.: Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity

  • First paper that shows that partial reprogramming reduces epigenetic age

2020

• Sarkar et al.: Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells

  • Commercialization: Turn Biotechnologies

• Matellan et al.: In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice

• Lu et al.: Reprogramming to recover youthful epigenetic information and restore vision

  • Commercialization: Iduna Therapeutics (part of Life Biosiences)
    

2021

• Gill et al.: Multi-omic rejuvenation of human cells by maturation phase transient reprogramming

• Alle et al.: A single short reprogramming early in life improves fitness and increases lifespan in old age

• Roux et al.: Partial reprogramming restores youthful gene expression through transient suppression of cell identity

• Wang et al.: In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche

• Chen et al.: Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice

2022

• Chondronasiou et al.: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming

• Browder et al.: In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice

• Cheng et al.: Partial reprogramming strategy for intervertebral disc rejuvenation by activating energy switch

• Hishida et al.: In vivo partial cellular reprogramming enhances liver plasticity and regeneration

• Ribeiro et al.: In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan

• Parras et al.: In vivo reprogramming leads to premature death due to hepatic and intestinal failure

2023

2024

• Vilchez-Acosta et al.: Neuron-specific partial reprogramming in the dentate gyrus impacts mouse behavior and ameliorates age-related decline in memory and learning

• Sahu et al. (Altos Labs): Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging